Exudative (wet) age-related macular degeneration (AMD) is a leading cause of vision loss in older adults, typically treated with intravitreal injections. Emerging therapies, such as subretinal injections of stem cells, gene therapy, small molecules or RPE cells require precise delivery to avoid damaging delicate retinal structures. Autonomous robotic systems can potentially offer the necessary precision for these procedures. This paper presents a novel approach for motion compensation in robotic subretinal injections, utilizing real-time Optical Coherence Tomography (OCT). The proposed method leverages B$^{5}$-scans, a rapid acquisition of small-volume OCT data, for dynamic tracking of retinal motion along the Z-axis, compensating for physiological movements such as breathing and heartbeat. Validation experiments on \textit{ex vivo} porcine eyes revealed challenges in maintaining a consistent tool-to-retina distance, with deviations of up to 200 $\mu m$ for 100 $\mu m$ amplitude motions and over 80 $\mu m$ for 25 $\mu m$ amplitude motions over one minute. Subretinal injections faced additional difficulties, with horizontal shifts causing the needle to move off-target and inject into the vitreous. These results highlight the need for improved motion prediction and horizontal stability to enhance the accuracy and safety of robotic subretinal procedures.

A one dimensional model of primate smooth pursuit mechanism has been implemented in 2 11m CMOS VLSI. The model consolidates Robinson's negative feedback model with Wyatt and Pola's positive feedback scheme, to produce a smooth pursuit system which zero's the velocity of a target on the retina. Furthermore, the system uses the current eye motion as a predictor for future target motion. Analysis, stability and biological correspondence of the system are discussed. For implementation at the focal plane, a local correlation based visual motion detection technique is used. Velocity measurements, ranging over 4 orders of magnitude with 15% variation, provides the input to the smooth pursuit system. The system performed successful velocity tracking for high contrast scenes. Circuit design and performance of the complete smooth pursuit system is presented.

A one dimensional model of primate smooth pursuit mechanism has been implemented in 2 11m CMOS VLSI. The model consolidates Robinson's negative feedback model with Wyatt and Pola's positive feedback scheme, to produce a smooth pursuit system which zero's the velocity of a target on the retina. Furthermore, the system uses the current eye motion as a predictor for future target motion. Analysis, stability and biological correspondence of the system are discussed. For implementation at the focal plane, a local correlation based visual motion detection technique is used. Velocity measurements, ranging over 4 orders of magnitude with 15% variation, provides the input to the smooth pursuit system. The system performed successful velocity tracking for high contrast scenes. Circuit design and performance of the complete smooth pursuit system is presented.

A one dimensional model of primate smooth pursuit mechanism has been implemented in 2 11m CMOS VLSI. The model consolidates Robinson's negative feedback model with Wyatt and Pola's positive feedback scheme, to produce a smooth pursuit system which zero's the velocity of a target on the retina. Furthermore, the system uses the current eye motion as a predictor for future target motion. Analysis, stability and biological correspondence of the system are discussed. For implementation at the focal plane, a local correlation based visual motion detection technique is used. Velocity measurements, ranging over 4 orders of magnitude with 15% variation, provides the input to the smooth pursuit system. The system performed successful velocity tracking for high contrast scenes. Circuit design and performance of the complete smooth pursuit system is presented.